Welcome to The Audette Lab

The K122-4 Pilin

 


 

We are a member of York University's Centre for Research on Biomolecular Interactions (CRBI).

 

For more details on the particular systems we are currently investigating, check out our Research and Publications pages. If you are interested in joining the lab, please read the Information for Prospective Trainees for info on the best way to get a hold of us.

Research in our lab focuses on understanding how proteins function at the structural level. We employ a variety of biochemical and biophysical techniques, however our primary tool is protein X-ray crystallography. Through a detailed knowledge of what a protein looks like in three dimensions, we can understand how these proteins function (or don't) in their biologial role.

 

Detailed knowledge of a protein's stucture also allows one to gain an understanding of how we might affect its function through mutation. For example, in the case of drug targets a detailed understading of a target protein's structure can aid the the development of a structurally-based therapeutic. Also, detailed structural information can lead to development of protein-based systems for nanotechnological applications.

 

Research in our lab is generally a mix of "wet" experiments (including protein expression, purification and crystallization), and "dry" experiments (structure solution, refinement and analysis). Currently, our research focus is structure determination and analysis. As our research program expands, our protein targets will be subjected to a variety of biochemial and biophysical analyses.