Antibiotic Resistance in Bacteria

MIME-Version: 1.0 Content-Type: multipart/related; boundary="----=_NextPart_01C7553B.D43D3140" This document is a Single File Web Page, also known as a Web Archive file. If you are seeing this message, your browser or editor doesn't support Web Archive files. Please download a browser that supports Web Archive, such as Microsoft Internet Explorer. ------=_NextPart_01C7553B.D43D3140 Content-Location: file:///C:/904A9932/Research2.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" Antibiotic Resistance in Bacteria

Research Outline

Antibiotic Resistance in Bacteria

Bacterial inf= ections have become a very serious issue of public health as a result of resistance developed or acquired toward almost all the antibiotics that are in use today. It has become clear that bacteria have the potential to develop resistance fairly easy toward an antibiotic due to the high mutagenesis rat= e of its genome and the genetic cross-talking among bacteria. Our focus is to understand the signaling mechanisms involved in induction of antibiotic resistance factors in pathogenic bacteria and especially in methicillin-resistant Staph= ylococcus aureus. This strain has acquired resistance to almost all= the clinically used antibiotics including vancomycin, an antibiotic of the last resort.

Drug resis= tance

The phenomeno= n of bacterial and viral resistance has raised the questions: Can we inhibit bacterial or viral infections without giving rise to resistance. To put it differently: Is there a resistance-proof biological target? If this i= s possible, then what biological properties a resistance-proof target should have? = ;Our group is investigating the answers to these questions and the solutions to these problems.

Human immunodeficiency (HIV) viral infection

Two main stra= tegies have been pursued in inhibiting the HIV infection: (1) developing vaccines = and (2) designing small molecules, organic- or peptide-based drugs that inhibit different stages of virus life-cycle. However, development of resistance has compromised the success in these efforts i.e. virus evolves to acquire a resistance when exposed to a neutralizing antibody or a drug.

Our group is interested in looking closely at the fusion process of HIV virus with the h= ost cell, and proteins involved in this step. The envelope glycoprotein complex is of special interest. Chemical and biological tools will be used to study the protein-protein interactions involved in the formation of this complex and biophysical methods will be used to quantitatively analyze these interactions.

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