BIOL 5143 3.0 Cr= 3.0
NEUROBIOLOGY OF DISEASE
Cross-Listed with KAHS 6154 3.0
KINESIOLOGY IS HOST Graduate Program
Course Description:
This course will focus on molecular and cellular mechanisms that give rise to disease in the developing and mature nervous system. The contribution of genetic, developmental and environmental factors in the causation of human diseases will be specifically addressed.
The course will provide graduate students with an in depth analysis of the molecular and cellular mechanisms that give rise to human disease in the developing and mature nervous system. This course examines how a combination of genes, developmental modifications and environmental factors contributes to changes in brain activity that in turn leads to both structural and functional remodeling of the brain and subsequently to a wide variety of neurological and psychiatric illnesses. This course discusses a variety of methodologies used in modern neuroscience research for studying mechanisms of human diseases and finding better treatment options. Selected diseases will be chosen by predominant age of onset: childhood (autism, ADHD), adolescence (schizophrenia), adulthood (Multiple Sclerosis, Lou Gehrig’s disease, Huntington's disease) and old age (Alzheimer's disease, Parkinson's disease).
The course will include two parts, (i) Formal didactic teaching sessions (provided by the course director) which will discuss clinical presentation of the disease, molecular mechanisms underlying the disease and current treatments, and (ii) Research seminars / chalk talks(given by students) in which students will write a critique and present research article describing a particular disease. In addition, students will be required to write a term paper on a topic of the student’s choice, related to topics covered in class.
Course Director:
Dr. Dorota Anna Crawford
346 Bethune College
Tel: 416-736-2100 ext: 23324
e-mail: dakc@yorku.ca
Evaluation:
Final mark will be based on
Class presentations and written critiques of research articles 40%
Class discussions and attendance 10%
Term paper 50%
Bibliography:
Corcione A, Aloisi F, Serafini B, Capello E, Mancardi GL, Pistoia V, Uccelli A. B-cell differentiation in the CNS of patients with multiple sclerosis. Autoimmun Rev. 2005 Nov;4(8):549-54.
Cordes SP. Molecular genetics of the early development of hindbrain serotonergic neurons. Clin Genet. 2005 Dec;68(6):487-94.
de Castro F, Bribian A. The molecular orchestra of the migration of oligodendrocyte precursors during development. Brain Res Brain Res Rev. 2005 Sep;49(2):227-41.
DiCicco-Bloom E, Lord C, Zwaigenbaum L, Courchesne E, Dager SR, Schmitz C, Schultz RT, Crawley J, Young LJ. The developmental neurobiology of autism spectrum disorder. J Neurosci. 2006 Jun 28;26(26):6897-906.
Di Prospero NA, Fischbeck KH. Therapeutics development for triplet repeat expansion diseases. Nat Rev Genet. 2005 Oct;6(10):756-65.
Freedman R. Schizophrenia. N Engl J Med. 2003 Oct 30;349(18):1738-49.
Ishizuka K, Paek M, Kamiya A, Sawa A. A review of Disrupted-In-Schizophrenia-1 (DISC1): neurodevelopment, cognition, and mental conditions. Biol Psychiatry. 2006 Jun 15;59(12):1189-97.
Jack C, Ruffini F, Bar-Or A, Antel JP. Microglia and multiple sclerosis. J Neurosci Res. 2005 Aug 1;81(3):363-73.
Kim SU, de Vellis J. Microglia in health and disease. J Neurosci Res. 2005 Aug 1;81(3):302-13.
Klauck SM. Genetics of autism spectrum disorder. Eur J Hum Genet. 2006 Jun;14(6):714-20.
Levitt P. Developmental neurobiology and clinical disorders: lost in translation? Neuron. 2005 May 5;46(3):407-12.
Lindvall O, Kokaia Z. Stem cells for the treatment of neurological disorders. Nature. 2006 Jun 29;441(7097):1094-6.
Maki P, Veijola J, Jones PB, Murray GK, Koponen H, Tienari P, Miettunen J, Tanskanen P, Wahlberg KE, Koskinen J, Lauronen E, Isohanni M. Predictors of schizophrenia-a review. Br Med Bull. 2005 Jun 9;73-74:1-15.
McCaffery P, Deutsch CK. Macrocephaly and the control of brain growth in autistic disorders. Prog Neurobiol. 2005 Sep-Oct;77(1-2):38-56. Epub 2005 Nov 8.
Meyer-Lindenberg A, Mervis CB, Berman KF. Neural mechanisms in Williams syndrome: a unique window to genetic influences on cognition and behaviour. Nat Rev Neurosci. 2006 May;7(5):380-93.
Moretti P, Zoghbi HY. MeCP2 dysfunction in Rett syndrome and related disorders. Curr Opin Genet Dev. 2006 Jun;16(3):276-81. 2006 May 2.
Moy SS, Nadler JJ, Magnuson TR, Crawley JN. Mouse models of autism spectrum disorders: the challenge for behavioral genetics. Am J Med Genet C Semin Med Genet. 2006 Feb 15;142(1):40-51.
Panyi G. Biophysical and pharmacological aspects of K+ channels in T lymphocytes. Eur Biophys J. 2005 Aug;34(6):515-29.
Powell CM, Miyakawa T. Schizophrenia-relevant behavioral testing in rodent models: a uniquely human disorder? Biol Psychiatry. 2006 Jun 15;59(12):1198-207.
Rehn AE, Rees SM. Investigating the neurodevelopmental hypothesis of schizophrenia. Clin Exp Pharmacol Physiol. 2005 Sep;32(9):687-96.
Riley B, Kendler KS. Molecular genetic studies of schizophrenia. Eur J Hum Genet. 2006 Jun;14(6):669-80.
Selkoe DJ. Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases. Nat Cell Biol. 2004 Nov;6(11):1054-61.
van Dellen A, Grote HE, Hannan AJ. Gene-environment interactions, neuronal dysfunction and pathological plasticity in Huntington's disease. Clin Exp Pharmacol Physiol. 2005 Dec;32(12):1007-19.
