The Sweeney Lab

Eguchi M, Kim YH, Kang KW, Dorval T, Shim CY, Jang YS & Sweeney, G.

Diabetes confers time-dependent alterations in cardiac structure and function after ischemia reperfusion injury.

PLoS One (2012) 7(2):e30450

Xu G, Ahn JH, Chang SY, Eguchi M, Ogier A, Han SJ, Park YS, Shim CY, Jang YS, Yang B, Song E, Xu A, Wang Y & Sweeney, G.

Lipocalin-2 induces cardiomyocyte apoptosis by increasing intracellular iron accumulation

Journal of Biological Chemistry (2012) 287(7):4808-17.

Jang, YS. Lee, JH. Wang, Y. & Sweeney, G.

Emerging clinical and experimental evidence for the role of lipocalin-2 in metabolic syndrome

Clinical and Experimental Physiology & Pharmacology (2012) 39(2):194-9

Abel, E.D. & Sweeney, G.

Modulation of the cardiovascular system by leptin

Biochimie (2012: Epub ahead of print)

Kim, OY. Lee, JH. Sweeney, G.

Plasma metabolite profiling as a useful tool for diagnosis and treatment of chronic disease: focus on obesity, diabetes and vascular aging

Expert Review of Cardiovascular Therapy (2012: accepted, in press)

Eguchi M, Xu G, Li RK & Sweeney, G.

Diabetes influences cardiac extracellular matrix remodeling after myocardial infarction and subsequent development of cardiac dysfunction

Journal of Cellular and Molecular Medicine (2012: in revision)

Liu, Y. Turdi, S. Park, T. Morris, NJ. Deshaies, Y. Xu, A. & Sweeney, G.

Adiponectin corrects high fat diet-induced disturbances in muscle metabolomic profile and whole body glucose homeostasis

Diabetes (2012: in revision)

Park, M. Park, T. Choi, CS. Wu, D. Cheng, KKY. Xu, A. & Sweeney, G.

APPL1 Transgenic Mice Are Protected From High Fat Diet-Induced Cardiomyopathy

Cardiovarcular Research (2012: submitted)

Park, M. & Sweeney, G.

Direct effects of adipokines on the heart

Heart Failure Reviews (2012: submitted)

Vu, V. Liu, Y. Bui, P. Xu, A. & Sweeney, G.

Tissue specific delivery of adiponectin gene to skeletal muscle using ultrasound targeted microbubble gene delivery is sufficient to improve whole body glucose homeostasis.

Diabetes (2012: submitted)

Schram, K. Shim CY, Xu G, Jang, YS & Sweeney, G.

Selective leptin resistance (hypothalamic v myocardial) occurs in diet-induced obese mice: influence on pressure overload-induced cardiac remodeling in pressure-overload hypertrophy in diet-induced obesity

FEBS Journal (2012: submitted)

Cheng, KKY., Lam, KSL., Wu, D., Wang, Y., Wang, Y., Sweeney, G., Hoo, RLC., Zhang, J. & Xu, A.

APPL1 potentiates insulin secretion in pancreatic β cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice.

Proc Natl Acad Sci USA. (2012) 109(23):8919-24

Lambertucci, RH. Silveira, LDR. Curi, R. Sweeney, G. & Pithon-Curi, TC.

Effects of moderate electrical stimulation on reactive species production by primary rat skeletal muscle cells: relationship between superoxide and nitric oxide production

Journal of Cellular Physiology (2012) 227(6):2511-8

Yang B. Fan P. Xu A. Lam KSL. Berger T. Mak TW. Tse HF. Yue JWS. Song E. Vanhoutte PE. Sweeney, G. & Wang Y.

Improved functional recovery to I/R injury in hearts from lipocalin-2 deficiency mice: restoration of mitochondrial function and phospholipids remodeling.

American Journal of Translational Research (2012) 4(1):60-71

Paik JK, Kim JY, Kim OY, Lee Y, Jeong TS, Sweeney, G., Jang Y, & Lee JH.

Circulating and PBMC Lp-PLA2 associate differently with oxidative stress and subclinical inflammation in nonobese women (menopausal status).

PLoS One. (2012) 7(2):e29675.

Lee, CJ, Kim, KJ, Kim, JS, Hur, J, Sweeney, G., Retnakaran R, Ko, YG, Hong, MK, Jang, YS, & Choi, DH

Correlation of Plasma Adiponectin Level and Infarct Size in ST Elevation Myocardial Infarction (STEMI) Measured by Cardiac Magnetic Resonance Imaging.

Circulation Journal (2012: submitted)

Ganguly R, Schram K, Fang X, Kim M, Rodrigues B, Thong F & Sweeney, G.

Adiponectin increases LPL activity via RhoA/ROCK-mediated actin remodelling in adult rat cardiomyocytes.

Endocrinology (2011) 152(1):247-54

Park, M. Youn, BS. Zheng, XL. Wu, D. Xu, A & Sweeney, G.

Adiponectin prevents hypoxia/reoxygenation-induced apoptosis in cardiomyocytes via AdipoR1/APPL1 signaling.

PLoS One (2011) 6(4):e19143

Schram, K. Ganguly, R. No, EK. Fang, X. Thong, F & Sweeney G.

Regulation of MT1-MMP by leptin in cardiac fibroblasts involves RhoA/ROCK-dependent cytoskeletal reorganization and is associated with altered MMP-2 activity.

Endocrinology (2011) 152(5):2037-47

Marette, A. & Sweeney, G.

Recent insights in cardiovascular complications of diabetes

Expert Reviews in Endocrinology & Metabolism (2011) 6(5), 689–696 (2011)

Dadson K, Liu Y, & Sweeney, G.

Adiponectin action: a combination of endocrine and autocrine/paracrine effects.

Frontiers in Cellular Endocrinology (2011) 2:62;1-14

Wang Y. Cheng KKY. Lam KSL. Wu D. Wang Y. Huang Y. Vanhoutte PM. Sweeney G. Li Y. & Xu A.

APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice.

Diabetes (2011) 60(11):3044-54

Zhang X, Xu A, Chung SK, Cresser JHB, Sweeney, G., Won RLC, Lin, A & Lam, KSL.

Selective inactivation of c-Jun NH2 terminal kinase in adipose tissue protects against diet-induced obesity and improves insulin sensitivity in both liver and skeletal muscle in mice.

Diabetes (2011) 60(2):486-95

Gao, X. Li, K. Hui, X. Kong, X. Sweeney, G. Wang, Y. Xu, A. Teng, M. Liu, P & Wu, D.

Carnitine palmitoyltransferase-1A prevents free fatty acid induced adipocyte dysfunction through suppression of c-Jun N-terminal kinase

Biochemical Journal (2011) 435(3):723-32

Chae JS. Kim OY. Paik JK. Kang RW Ju SW. Jeong TS. Sweeney G. Lee SH & Lee JH

Association of Lp-PLA2 activity and LDL size with interleukin-6, an inflammatory cytokine and oxidized LDL, a marker of oxidative stress in women with metabolic syndrome.

Atherosclerosis (2011) 218(2):499-506

Sweeney G.

Cardiovascular effects of leptin.

Nature Reviews Cardiology (2010) 7(1):22-9

Fang X. Palanivel R. Cresser J. Schram K. Tuinei J. Xu A. Abel ED. & Sweeney G.

Adiponectin Regulates Fatty Acid uptake and Metabolism in Cardiomyocytes via an APPL1-dependent Mechanism

American Journal of Physiology:Endocrinology & Metabolism (2010) 299(5):E721-9

Law IKM. Xu A. Lam KSL. Berger T. Mak TW. Vanhoutte PM. Liu JTC. Sweeney G. Zhou M & Wang Y.

Protection against developing insulin resistance in mice lacking lipocalin-2.

Diabetes (2010) 59(4):872-82

Sommer, P & Sweeney G.

Functional and mechanistic integration of infection and the metabolic syndrome

Korean Diabetes Journal (2010) 34(2):71-6

Vu V, Dadson K, Odisho T, Kim W, Zhou X, Thong F, Xu A & Sweeney G.

Temporal analysis of mechanisms leading to stimulation of glucose uptake in skeletal muscle cells by an adipokine mixture derived from primary rat adipocytes

International Journal of Obesity (2010) Epub ahead of print

Schram K, De Girolamo S, Madani S, Munoz D, Thong F & Sweeney G.

Leptin regulates MMP-2, TIMP-1 and collagen synthesis via p38 MAPK in HL-1 murine cardiomyocytes

Cell & Molecular Biology Letters (2010) 15(4):551-63

Rose JB, Naydenova Z, Bang A, Eguchi M, Sweeney G., Choi DS, Hammond JR & Coe IR.

Equilibrative nucleoside transporter 1 plays an essential role in cardioprotection

American Journal of Physiology: Heart & Circ (2010) 298(3):H771-7

Lee KR, Sweeney G., Kim WY & Kim KK

Serum Ferritin Was linked with Aortic Stiffness in apparently healthy Korean Women

Critical Pathways in Cardiology (2010) 9(3):160-3

Shabani DM, Vu V, Robson-Doucette CA, Sweeney G. & Wheeler MB.

Insulin mimetics in Urtica dioica.

Phytotherapy Research (2010) 24 S2:S175-82

Wijesekara, N. Krishnamurthy, M. Bhattacharjee, A. Suhail, A. Sweeney G. & Wheeler, MB.

Adiponectn induced ERK and Akt phosphhorylation protects against pancreatic β cell apoptosis.

Journal of Biological Chemistry (2010) 285(44):33623-31

Sweeney G.

Unraveling the mechanisms linking obesity and heart failure: the role of adipokines (Editorial comment).

Expert Reviews of Endocrinology and Metabolism (2009) 4(2):95-97

Liu, Y. Chewchuk, S. Lavigne, C. Brûlé, S. Pilon, G. Houde, V. Xu, A. Marette, A. & Sweeney G.

Functional significance of skeletal muscle adiponectin production, changes in animal models of obesity and diabetes and regulation by rosiglitazone treatment.

American Journal of Physiology: Endocrinology & Metabolism (2009) 297(3):E657-64

Shin, EJ., Schram, K., Zheng, XL. & Sweeney G.

Leptin attenuates hypoxia/reoxygenation-induced apoptosis in rat H9c2 cardiomyocytes.

Journal of Cellular Physiology (2009) 221(2):490-7

Fang, X. Fetros, J. Dadson, KE. Xu, A. & Sweeney G.

Leptin prevents insulin-mimetic and insulin-sensitizing effects of adiponectin in rat skeletal muscle cells.

Diabetologia (2009) 52(10):2190-200

Schram, K. & Sweeney G.

Implications of myocardial matrix remodeling by adipokines in obesity-related heart failure

Trends in Cardiovascular Medicine (2009) 18(6):199-205

Cheng, KKY., Iglesias, MA., Lam, KSL., Wang, Y., Sweeney, G., Zhu, G., Vanhoutte, P., Kraegen, EW. & Xu, A.

APPL1 potentiates hepatic insulin sensitivity on inhibition of glucose production and alleviates diabetes via Akt activation in mice

Cell Metabolism (2009) 9(5):417-27

Gao, X. Chen, W. Xu, A. Wang, Z.m Sweeney G. & Wu, D.

Peripheral insulin resistance is associated with altered CPT1 activity in CNS of CPT1C mice fed a high fat diet.

Diabetologia (2009) 52:912-920

Xu A, Wang H, Hoo RL, Sweeney G., Vanhoutte PM, Wang Y, Wu D, Chu W, Qin G, Lam KS.

Selective elevation of adiponectin production by the natural compounds derived from a medicinal herb alleviates insulin resistance and glucose intolerance in obese mice.

Endocrinology (2009) 150(2):625-33

Retnakaran, R. Youn, BS. Liu, Y. Hanley, AJG. Lee, NS. Park, JW. Song, ES. Vu, V. Kim, W. Tungtrongchitr, R. Havel, PJ. Swarbrick, MM. Shaw, C. & Sweeney G.

Correlation of circulating full-length visfatin (PBEF/NAMPT) with metabolic parameters in subjects with and without diabetes: a cross-sectional study.

Clinical Endocrinology (2008) 69(6):885-93

Palanivel R, Vu V, Park M, Fang X & Sweeney G.

Differential impact of adipokines derived from primary adipocytes of wild-type versus streptozotocin-induced diabetic rats on glucose and fatty acid metabolism in cardiomyocytes.

Journal of Endocrinology (2008) 199(3):389-97

Abel, ED. Litwin, SE. & Sweeney G.

Cardiac remodeling in obesity.

Physiological Reviews (2008) 88(2):389-419

Krause, MP. Liu, Y. Vu, V. Chan, L. Xu, A. Riddell, MC., Sweeney G. & Hawke, TJ.

Adiponectin is expressed by skeletal muscle fibres and influences muscle phenotype and function.

American Journal of Physiology (2008) 295(1):C203-12

Teoh, H. Quan, A. Bang, KWA. Wang, G. Lovren, F. Vu, V. Haitsama, JJ. Szmitko, PE. Wang, CH. Gupta, M. Peterson, MD. Zhang, H. Chan, LC. Freedman, J., Sweeney G. & Verma, S.

Adiponectin deficiency promotes endothelial activation and profoundly exacerbates sepsis-related mortality.

American Journal of Physiology (2008) 295(3):E658-64

Schram, K. Palanivel, R. Wong, MC. No, EK. Dixon, IMC. & Sweeney G.

Leptin stimulates MMP-2 activity via increased expression and cell surface localization of MT1-MMP in neonatal rat cardiac myofibroblasts.

Journal of Molecular & Cellular Cardiology (2008) 44(5):874-81.

Eguchi, M. Liu, Y. Shin, W. Zheng, XL. & Sweeney G.

Leptin protects rat cardiomyocytes from H2O2-induced apoptosis

FEBS Journal (2008) 275(12):3136-44

Vu, V. Riddell, M. & Sweeney G.

Effects of exercise on adiponectin: circulating levels and receptor expression.

Diabetes Metabolism Research and Reviews (2007) 23(8):600-611

Vu, V. Kim, W. Fang, X. Liu, Y. Xu, A. & Sweeney G.

Coculture with primary visceral rat adipocytes from control but not streptozotocin-induced diabetic animals increases glucose uptake in rat skeletal muscle cells: role of adiponectin.

Endocrinology (2007) 148(9):4411-9

Liu, Y. Retnakaran, R. Hanley, A. Tungtrongchitr, R. Shaw, C. & Sweeney G.

High molecular weight (HMW) but not trimeric or hexameric forms of adiponectin correlate with markers of the metabolic syndrome in Thai subjects.

Journal of Clinical Endocrinology and Metabolism (2007) 92(11):4313-8

Palanivel, R. Fang, X. Park, M. Eguchi, M. Pallan, S. DeGirolamo, S. Liu, Y. Wang, Y. Xu, A. & Sweeney G.

Globular and full-length adiponectin mediate specific changes in glucose and fatty acid uptake and metabolism in cardiomyocytes.

Cardiovascular Research (2007) 75(1):148-57

Eguchi, M. Shrivastava, S. Lyakhovsky, N. Kim, W. Palanivel, R. & Sweeney G.

Functional consequences of leptin-induced SOCS-3 expression and its co-localization with insulin receptor in rat skeletal muscle cells.

Journal of Endocrinological Investigation (2007) 30(3):192-9

Eguchi, M. Gillis, LC. Liu, Y. Lyakhovsky, N. Du, M. McDermott, JC & Sweeney G.

Regulation of SOCS-3 expression by leptin and its co-localization with insulin receptor in rat skeletal muscle cells

Molecular and Cellular Endocrinology (2007) 267(1-2):38-45

Wang, Y. Lam, KSL. Kraegen, E. Sweeney G. Zhang, J. Tso, AWK. Chow, WS. Wat, NMS. Xu, JY. Hoo, RCL & Xu, A.

Lipocalin-2 is an inflammatory marker closely associated with obesity. Insulin resistance and hyperglycemia in humans.

Clinical Chemistry (2007) 53(1):34-41

Fang, X. & Sweeney G.

Mechanisms regulating energy metabolism by adiponectin in obesity & diabetes

Biochemical Society Transactions (2006) 34(Pt 5):798-801

Madani, S., De Girolamo, S., Munoz, D., Li, RK. & Sweeney G.

Direct effects of leptin on size and extracellular matrix components of human pediatric ventricular myocytes

Cardiovascular Research (2006) 69(3):716-25

Palanivel, R, Maida, M., Liu, Y. & Sweeney G.

Regulation of insulin signaling, glucose uptake and metabolism in rat skeletal muscle cells upon prolonged exposure to resistin.

Diabetologia (2006) 49(1):183-90

Palanivel, R, Eguchi, M, Shuralyove, I, Coe, I. & Sweeney G.

Distinct effects of short and long term leptin treatment on glucose and fatty acid uptake and metabolism in HL-1 cardiomyocytes

Metabolism (2006) 55(8):1067-75

Lee, M. & Sweeney G.

Insulin increases gelatinase activity in rat glomerular mesangial cells via ERK- and PI-3 kinase-dependent signaling

Diabetes, Obesity & Metabolism (2006) 8(3):281-288

Fang, X, Palanivel, R, Zhou, X, Liu, Y, Xu, A, Wang, Y & Sweeney G.

Regulation of adiponectin receptor expression and metabolic effects of globular and full-length adiponectin in rat skeletal muscle cells by hyperglycemia and hyperinsulinemia.

Journal of Molecular Endocrinology (2005) 35(3):465-76

Ceddia, RB., Somwar, R., Maida, A., Fang, X., Bikopoulos, G. & Sweeney G.

Globular adiponectin increases GLUT4 translocation and glucose uptake but reduces glycogen synthesis in rat skeletal muscle cells

Diabetologia (2005) 48(1):132-9

Palanivel, R & Sweeney G.

Regulation of fatty acid uptake and metabolism in L6 skeletal muscle cells by resistin.

FEBS Letters (2005) 579(22):5049-54

Somwar, R., Fang, X. & Sweeney G.

Models of type 2 diabetes

Drug Discovery Today (2005) 2(3):183-189

Lee, M.P. Orlov, D. Bikopoulos, G. Ceddia, R. Sekula, S. & Sweeney G.

Leptin induces rat glomerular mesangial cell hypertrophy but does not regulate hyperplasia or apoptosis.

International Journal of Obesity (2005) 29(12):1395-401

Lee, M.P., Madani, S., Sekula, D. & Sweeney G.

Leptin increases expression and activity of matrix metalloproteinase-2 and does not alter collagen production in rat glomerular mesangial cells

Endocrine Research (2005) 31(1): 27-37

Tajmir, P., Ceddia, R.B., Li, RK., Coe, I.R. & Sweeney G.

Leptin increases hyperplasia in cardiac myocytes via ERK- and PI 3-kinase-dependent signaling pathways

Endocrinology (2004) 145(4):1550-5

Ceddia, R.B. & Sweeney G.

Creatine increases glucose oxidation and AMPK phosphorylation and reduces lactate production in rat skeletal muscle cells.

Journal of Physiology (2004) 555(2):409-21

Sweeney G, Garg, R, Ceddia, R, Li, D, Ishiki, M, Somwar, R, Foster, L, Neilsen, P, Prestwich, G, Jiang, T, Rudich, A & Klip, A.

Intracellular delivery of phosphatidylinositol (3,4,5)-trisphosphate causes translocation and incorporation of GLUT4 into the plasma membrane of muscle and fat cells without increasing transport.

Journal of Biological Chemistry (2004) 279(31):32233-42

Shuralyova, I., Tajmir, P., Sweeney G., & Coe, I.R.

Inhibition of glucose transport in cardiomyocytes by the cardiovascular drugs, dipyridamole and dilazep.

American Journal of Physiology (2004) 286(2):H627-32

Bikopoulos, G., Ceddia, RB., Sweeney G. & Hilliker, AJ

Insulin reduces apoptosis and increases DNA synthesis and cell size via distinct signaling pathways in Drosophila Kc cells

Cell Proliferation (2004) 37(4):307-16

Tajmir, P., Kwan, J., Kessas, M., Mozammel, S. & Sweeney G.

Effect of chronic leptin on insulin signaling and glucose transport in L6-GLUT4myc cells.

Journal of Cellular Physiology (2003) 197(1):122-30

Ceddia, R.B., Bikopoulos, G.J., Hilliker, A.J. & Sweeney G.

Insulin stimulates glucose metabolism via the pentose phosphate pathway in Drosophila Kc cells.

FEBS Letters (2003) 555(2):307-10

Moon, B., Kwan, J., Duddy, N., Sweeney G. & Begum, N.

Expression of resistin inhibits glucose uptake in rat L6 skeletal muscle cells without affecting Glut-4 translocation and Insulin signaling through IRS-1/PI3-kinase.

American Journal of Physiology (2003) 285(1):E106-15

Ceddia, RB. Koistinen, HA., Zierath, JR. & Sweeney G.

Analysis of paradoxical observations on the association between leptin and insulin resistance.

FASEB Journal (2002) 16(10): 1163-1176

Sweeney G.

Leptin Signalling.

Cellular Signallin (2002) 14: 655-663

Somwar, R., Koteski, S., Sweeney G., Sciotti, R., Djuric, S., Trevillyan, J., Berg, C., Scherrer, P. E., Rondinone, C. M. & Klip, A.

A dominant-negative p38 MAPK mutant and novel selective inhibitors of p38 MAPK reduce insulin-stimulated glucose uptake in 3T3-L1 adipocytes.

Journal of Biological Chemistry (2002) 277(52) 50386-95

Konrad, D., Bilan, P, Nawaz, Z, Sweeney G., Niu, W., Liu, Z, Antonescu, C, Rudich A, & Klip, A.

Need for GLUT4-activation to reach maximum effect of insulin-mediated glucose uptake in brown adipocytes isolated from GLUT4myc-expressing mice.

Diabetes (2002) 51(9): 2719-2726

Furtado, L. M., Somwar, R., Sweeney G., Niu, W. & Klip, A.

Activation of the glucose transporter GLUT4 by insulin.

Biochemistry and Cell Biology (2002) 80(5): 569-578

Chaudary, N., Shuralyova, I., Liron, T., Sweeney G. & Coe, IR.

Transport characteristics of HL-1 cells; a new model for the study of adenosine physiology in cardiomyocytes.

Biochemistry and Cell Biology (2002) 80(5): 655-665