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RESEARCH PROFILES

Sergey Krylov

Sergey Krylov earned a PhD in chemistry from Moscow State University in 1990 and joined York's faculty in 2000. As CRC in bioanalytical chemistry at York, he leads research to develop novel methods for studying the molecular mechanisms of diseases and for engineering drugs and diagnostics.

Krylov's lab is developing a method of analyzing molecular mechanisms called chemical cytometry. Understanding the molecular mechanisms of many fundamental biological processes and serious health disorders requires simultaneous analysis of a large number of chemical species within single cells. Classical cytometries such as image cytometry and flow cytometry allow simultaneous assay of only a limited number of species. But chemical cytometry allows multi-component analysis of single cells by using capillary electrophoresis to separate cells and laser-induced fluorescence to detect them. Krylov’s lab is using chemical cytometry to study the molecular mechanisms of stem cells, cancer and Alzheimer's disease.