DOD CDMRP Program Announcements - Part 3

The following funding opportunities are in the areas of Neurofibromatosis, Tuberous Sclerosis Complex, and Peer Reviewed Medical research.  Summaries of each award mechanism are provided below.  Detailed descriptions of each funding mechanism and submission requirements can be found in the Program Announcements which are available electronically for downloading from the following web sites:
 
Grants.gov web site: http://www.grants.gov
 
The CDMRP web site: http://cdmrp.army.mil/funding/prgdefault.shtml and
 
The CDMRP eReceipt web site: https://cdmrp.org/
 
 
NEUROFIBROMATOSIS RESEARCH PROGRAM (NFRP)
 
1) Clinical Trial Award – (Funding Opportunity No.: W81XWH-12-NFRP-CTA)
 
Objectives
To support pilot and Phase 0, I, or II clinical trials with the potential to have a major impact on the treatment or management of NF. Funding from this award mechanism must support a clinical trial and may not be used for preclinical research studies.
Value
Up to $900K
 
Duration
Up to 4 years
 
Deadlines
Full application to ORS – May 17, 2012
Pre-application submission deadline – May 10, 2012, 5:00 p.m. Eastern Time (ET)
Full application to agency – May 31, 2012, 11:59 p.m. ET
 
Please consult the following web site for further information on this opportunity and how to apply:
http://cdmrp.army.mil/funding/pa/12nfrpcta_pa.pdf


2) Exploration – Hypothesis Development Award (Funding Opportunity No.:
 W81XWH-12-NFRP-EHDA)
 
Objectives
To support the initial exploration of innovative, high-risk, high-gain, and potentially groundbreaking concepts in the NF research field. The proposed work should provide initial principles of an innovative question/concept and results of studies conducted through this award may provide the scientific rationale upon which a new hypothesis can be based. This award is designed to provide investigators with the opportunity to pursue serendipitous observations. The presentation of preliminary data is encouraged, but not required.
 
Value
Up to $100K plus indirect costs
 
Duration
Up to 2 years
 
Deadlines
Full application to ORS – May 17, 2012
Pre-application submission deadline – May 10, 2012, 5:00 p.m. Eastern Time (ET)
Full application to agency – May 31, 2012, 11:59 p.m. ET
 
Please consult the following web site for further information on this opportunity and how to apply:
http://cdmrp.army.mil/funding/pa/12nfrpehda_pa.pdf
 
3) Investigator-Initiated Research Award (Funding Opportunity No.:
 W81XWH-12-NFRP-IIRA)
 
Objectives
To support innovative basic and clinically oriented research that will:
·         Provide insight into the development of NF, or into particular lesions or abnormalities which occur as a result of NF,
·         Result in substantial improvements over today’s approach to the diagnosis and treatment of NF, and
·         Have an impact on the quality of life of persons with those diseases.
 
Areas of Emphasis: The FY12 NFRP strongly encourages research applications that specifically address the critical needs of the NF community in the following areas of emphasis:
·         Cognitive and social dysfunction in the setting of NF
·         Drug discovery for the treatment of NF
·         Effects of aging, including hormonal changes and cardiovascular disease in the setting of NF
·         Epigenetics, including non-coding RNAs, such as microRNAs, in causation or progression of abnormalities from NF
·         Novel disease markers such as imaging and proteomics of NF
·         Pain in the setting of NF
·         Plexiform and dermal neurofibromas
·         Tumor heterogeneity in NF-associated neoplasia
   
Value
Up to $525K plus indirect costs 
If requesting an Optional Qualified Collaborator or Optional Nested Postdoctoral Traineeship, the maximum allowable direct costs for the entire period of performance are $675K plus indirect costs.
 
Duration
Up to 3 years
 
Deadlines
Full application to ORS – May 17, 2012
Pre-application submission deadline – May 10, 2012, 5:00 p.m. Eastern Time (ET)
Full application to agency – May 31, 2012, 11:59 p.m. ET
 
Please consult the following web site for further information on this opportunity and how to apply:
http://cdmrp.army.mil/funding/pa/12nfrpiira_pa.pdf
 
 
4) New Investigator Award (Funding Opportunity No.: W81XWH-12-NFRP-NIA)
 
Objectives
To support the continued development of promising independent investigators and/or the transition of established investigators into a career in the field of NF research. Experience in NF research is allowed, but not required. However, Principal Investigators (PIs) with a limited background in NF research are strongly encouraged to have a collaborator who is experienced in the NF field. New Investigator Award applications must include preliminary data that is relevant to NF and the proposed project.
 
Areas of Emphasis: The FY12 NFRP strongly encourages research applications that specifically address the critical needs of the NF community in the following areas of emphasis:
·         Cognitive and social dysfunction in the setting of NF
·         Drug discovery for the treatment of NF
·         Effects of aging, including hormonal changes and cardiovascular disease in the setting of NF
·         Epigenetics, including non-coding RNAs, such as microRNAs, in causation or progression of abnormalities from NF
·         Novel disease markers such as imaging and proteomics of NF
·         Pain in the setting of NF
·         Plexiform and dermal neurofibromas
·         Tumor heterogeneity in NF-associated neoplasia
 
Value
Up to $400K plus indirect costs. 
 
Duration
Up to 3 years
 
Deadlines
Full application to ORS – May 17, 2012
Pre-application submission deadline – May 10, 2012, 5:00 p.m. Eastern Time (ET)
Full application to agency – May 31, 2012, 11:59 p.m. ET
 
Please consult the following web site for further information on this opportunity and how to apply:
http://cdmrp.army.mil/funding/pa/12nfrpnia_pa.pdf
 
 
TUBEROUS SCLEROSIS COMPLEX RESEARCH PROGRAM (TSCRP)
 
1)      Clinical Trial Award (Funding Opportunity Number: W81XWH-12-TSCRP-CTA)
 
Objectives
To support pilot and Phase 0, I, or II clinical trials with the potential to have a major impact on the treatment or management of TSC.  Funding from this award mechanism must support a clinical trial and may not be used for preclinical research studies.
 
Value
Up to $1M plus indirect costs
 
Duration
Up to 4 years
 
Deadlines
Full application to ORS – May 17, 2012
Pre-application to agency – May 10, 2012, 5:00 p.m. Eastern Time (ET)
Full application to agency – May 31, 2012, 11:59 p.m. ET
 
Please consult the following web site for further information on this opportunity and how to apply:
http://cdmrp.army.mil/funding/pa/12tscrpcta_pa.pdf
 
2) Exploration – Hypothesis Development Award (Funding Opportunity No.:
 W81XWH-12-TSCRP-EHDA)
 
Objectives
To support the initial exploration of innovative, high-risk, high-gain, and potentially groundbreaking concepts in the TSC research field. The proposed work should provide initial principles of an innovative question/concept, and results of studies conducted through this award should provide the scientific rationale upon which a new hypothesis may be developed. This award is designed to provide investigators with the opportunity to pursue serendipitous observations. The presentation of preliminary data is encouraged, but not required.
 
Value
Up to $100K plus indirect costs
 
Duration
Up to 2 years
 
Deadlines
Full application to ORS – May 17, 2012
Pre-application submission deadline – May 10, 2012, 5:00 p.m. Eastern Time (ET)
Full application to agency – May 31, 2012, 11:59 p.m. ET
 
Please consult the following web site for further information on this opportunity and how to apply:
http://cdmrp.army.mil/funding/pa/12tscrpehda_pa.pdf
 
 
3) Idea Development Award (IDA) (Funding Opportunity No.: W81XWH-12-TSCRP-IDA)
 
Objectives
To support high-impact, innovative research that will drive the field of TSC research forward. Preclinical studies are encouraged, but clinical trials are not allowed.
 
Value
Up to $425K plus indirect costs.  If requesting an Optional Qualified Collaborator or Optional Nested Postdoctoral Traineeship, the maximum allowable direct costs for the entire period of performance are $575K plus indirect costs.
 
Duration
Up to 3 years
 
Deadlines
Full application to ORS – May 17, 2012
Pre-application submission deadline – May 10, 2012, 5:00 p.m. Eastern Time (ET)
Full application to agency – May 31, 2012, 11:59 p.m. ET
 
Please consult the following web site for further information on this opportunity and how to apply:
http://cdmrp.army.mil/funding/pa/12tscrpida_pa.pdf
 
 
PEER REVIEWED MEDICAL  RESEARCH PROGRAM (PRMRP)
 
1.      Clinical Trial Award (Funding Opportunity No.: W81XWH-12-PRMRP-CTA)
 
Objectives
To support the rapid implementation of clinical trials with the potential to have a significant impact on a disease or condition addressed in at least one of the Congressionally directed FY12 PRMRP topic areas. Clinical trials may be designed to evaluate promising new products, pharmacologic agents (drugs or biologics), devices, clinical guidance, and/or emerging approaches and technologies. Proposed projects may range from small proof-of-concept (i.e., pilot, first in human, or Phase 0) trials to demonstrate feasibility or inform the design of more advanced trials, through large-scale trials to determine efficacy in relevant patient populations. All studies must be responsive to the health care needs of the military service members, veterans, and/or beneficiaries; however, the use of military populations is not required.
 
Value
Up to $2.2M plus indirect costs
 
Duration
Up to 5 years
 
Deadlines
Full application to ORS – July 12, 2012
Pre-application to agency – June 6, 2012, 5:00 p.m. Eastern Time (ET)
Full Application to agency – July 26, 2012, 11:59 p.m. ET
 
Please consult the following web site for further information on this opportunity and how to apply:
http://cdmrp.army.mil/funding/pa/12prmrpcta_pa.pdf
 
2.      Discovery Award (Funding Opportunity No.: W81XWH-12-PRMRP-DA)
 
Objectives
To support innovative, untested, high-risk/ potentially high-reward concepts, theories, paradigms, and/or methods. Studies supported by this award are expected to lay the groundwork for future avenues of scientific investigation. The proposed research project should include a well-formulated, testable hypothesis based on strong scientific rationale and study design.
 
Value
Up to $125K plus indirect costs
 
Duration
Up to 18 months
 
Deadlines
Full application to ORS – May 10, 2012
Pre-application to agency – May 9, 2012, 5:00 p.m. Eastern Time (ET)
Full Application to agency – May 24, 2012, 11:59 p.m. ET
 
Please consult the following web site for further information on this opportunity and how to apply:
http://cdmrp.army.mil/funding/pa/12prmrpda_pa.pdf
 
3.      Technology/Therapeutic Development Award (Funding Opportunity No.: W81XWH-12-PRMRP-TTDA)
 
Objectives
To provide support for the translation of promising preclinical findings into products for clinical applications, including prevention, detection, diagnosis, patient care, and/or quality of life, in at least one of the Congressionally directed FY12 PRMRP topic areas. Products in development should be responsive to the health care needs of military service members, veterans, and/or beneficiaries.
 
Value
Up to $1.5M plus indirect costs
 
Duration
Up to 3 years
 
Deadlines
Full application to ORS – July 12, 2012
Pre-application to agency – June 6, 2012, 5:00 p.m. Eastern Time (ET)
Full Application to agency – July 26, 2012, 11:59 p.m. ET
 
Please consult the following web site for further information on this opportunity and how to apply:
http://cdmrp.army.mil/funding/pa/12prmrpttda_pa.pdf

ORS Submission Policy
York University researchers are reminded that all applications for external research funding, including Letters of Intent, must be reviewed and approved by the Office of Research Services before they are submitted to the granting agency. For internal approval, the application must be accompanied by a completed ORS Checklist, which requires the Chair’s and Dean’s signatures.

To ensure that the approved application is ready by the agency deadline, a complete application folder must be submitted to the ORS ten (10) working days prior to final submission date.