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Barkha P Patel, MSc

 

 

EDUCATION

 

2009 - 2013                                Doctor of Philosophy (PhD. Candidate)

Department of Nutritional Sciences, Faculty of Medicine

University of Toronto, Toronto, ON

 

Thesis: Interaction of environmental and physiological determinants of food intake control in children.

 

 

2006 – 2008                               Master of Science

School of Kinesiology and Health Science, Faculty of Health

York University, Toronto, ON

 

Thesis: The effects of long-term caloric restriction on molecular outcome measures in the Cu/Zn-SOD mutant G93A mouse, an animal model of amyotrophic lateral sclerosis (ALS).

 

 

2002 – 2006                               Honours Bachelor of Science

Honours Biology, Minor in English

McMaster University, Hamilton, ON

 

Fourth Year Independent Study: Long-term caloric restriction increases malondialdehyde  in the red and white gastrocnemius muscle in the Cu/Zn-SOD mutant G93A mouse, an animal model of ALS

 

 

AWARDS, SCHOLARSHIPS, & DISTINCTIONS

 

August 2009                              Doctoral Student Award in Nutrition Education and Communication. Presented by the Danone Institute of Canada.

 

May 2009                                   Ontario Graduate Scholarship (OGS). Declined

 

April 2009                                 First Place Prize

Cell and Molecular Physiology (CAMPS) Section Robert Gunn Student Award

Experimental Biology 2009, New Orleans, LA

                                                                                            

January 2009                            Graduate Student Award Competition Finalist.

Ontario Exercise Physiology (OEP) 2009, Barrie, ON

                                                                                            

April 2008                                 Nutrient-Gene Interaction (NGIRIS) Poster Competition Participant.

The American Society for Nutrition (ASN)

Experimental Biology 2007, San Diego, CA

 

April 2007                                 Caroline tum Suden/Frances A. Hellebrandt Professional Opportunity Award.

The American Physiological Society (APS)

Experimental Biology 2008, Washington, DC

 

Apr 2006                                   Honourable Mention

Biology Undergraduate Symposium

McMaster University

 

Sept 2002                                  McMaster Honour Award. Presented at the Undergraduate Academic Awards Ceremony.  

Awarded by McMaster University

 

June 2002                                 Zonta Club of Sault Ste. Marie Award

Ontario Scholar 

 

EMPLOYMENT EXPERIENCE

 

Nov 2008 – Dec 2008                Administrative Assistant: Specialty Casualty

Liberty International Underwriters, Brookfield Place, Toronto, ON

Supervisor: Mr. Garth Pepper

 

Sept 2008 – Nov 2008               Laboratory Assistant & Grant Writer

School of Kinesiology and Health Science, York University, Toronto, ON

Supervisor: Dr. Mazen J. Hamadeh

 

Jan 2008 – Apr 2008                 Teaching Assistant: Exercise Physiology KINE 4010 (Jan 2008)

School of Kinesiology and Health Science, York University, Toronto, ON

Course Coordinator: Dr. David A. Hood

 

Sept 2007 – Dec 2007               Teaching Assistant: Skilled Performance and Motor Learning KINE 3020

School of Kinesiology and Health Science, York University, Toronto, ON

Course Coordinator: Dr. Denise Henriques & Professor Merv Mosher

 

Sept 2007 – Dec 2007               Private Statistics Tutor: Univariate Analysis and Design KINE 6010

School of Kinesiology and Health Science, York University, Toronto, ON

 

Apr 2007 – Apr 2008                 Laboratory, Research & Technical Assistant

School of Kinesiology and Health Science, York University, Toronto, ON

Supervisor: Dr. Mazen J. Hamadeh

 

Jan 2007 – Apr 2007                 Teaching Assistant: Analysis of Data in Kinesiology I KINE 2050

School of Kinesiology and Health Science, York University, Toronto, ON

Course Coordinator: Dr. Hala Tamim & Dr. Chris Ardern

 

Sept 2006 – Dec 2006               Teaching Assistant: Human Physiology II KINE 3012

School of Kinesiology and Health Science, York University, Toronto, ON

Course Coordinator: Dr. Michael Connor

 

May 2006 – Aug 2006                Laboratory, Research & Animal Facility Assistant 

Dept. of Pediatrics, McMaster University Medical Centre, Hamilton, ON

Supervisor: Dr. Mark A. Tarnopolsky

 

 

COMMITTEE MEMBERSHIPS

 

Jan 2009 – Present                  Graduate Student Member of HISTORY (High Impact Strategies Towards Overweight

Reduction in Youth)

CIHR Childhood Obesity Research Team

Hospital for Sick Children, Toronto, ON

 

Sept 2007 – Sept 2008              Graduate Student Assembly (GSA) Councillor

York University, Toronto, ON

 

Sept 2005 – Apr 2006               Executive Board member

McMaster Students’ Union (MSU), McMaster University, Hamilton, ON

 

Apr 2004 – Apr 2006                 Student Representative Assembly (SRA) member

Faculty of Science, McMaster University, Hamilton, ON

 

Apr 2004 – Apr 2006                 Ontario Undergraduate Student Alliance (OUSA) delegate representing the MSU

McMaster University, Hamilton, ON

 

 

PROFESSIONAL MEMBERSHIPS


2008   Canadian Society for Nutritional Sciences (CSNS)

 

2007   American Physiological Society (APS)

 

2007   American Society for Nutrition (ASN)

 

2007   Canadian Obesity Network

 

 

TECHNICAL SKILLS


ACADEMIC RESEARCH SKILLS:  grant application submissions, grant proposals, oral  presentations, literature searches  

and manuscript preparation

 

ANIMAL RESEARCH SKILLS:  animal handling, injections and endpoint, exercise training of mice, pre-clinical

measurements (measuring body weight, food intake etc.), perfusion of whole animal for immunohistochemistry,

insertion of osmotic pumps in rats, surgical removal of muscle and tissue from mice, tail cutting and lysing.

 

LABORATORY RESEARCH SKILLS:  lab start-up (ordering and assembling equipment), spectrophotometric enzyme

assays, lipid peroxidation assay, protein carbonyl assay, protein quantification and analysis, western blotting and RT-PCR

 

CLINICAL RESEARCH SKILLS: research ethics preparations, patient recruitment (informed consent), bioelectrical impedance analysis (BIA) measurements, skinfold measurements, food intake measurements and administration of visual analogue scales (VAS)

 

 

VOLUNTEERING

 

June 2007                                 WALK for ALS participant, ALS Society of Ontario, Ontario Place, Toronto, ON

 

Sept 2006 – Present                  Research volunteer, Ontario Association of Food Banks (OAFB) volunteer, Toronto, ON

 

Sept 2002 – Apr 2006                Executive member, McMaster Wish Foundation, McMaster University, Hamilton, ON

 

 

EXTRACURRICULAR ACTIVITIES

 

Jogging & tennis

 

Strong interest in nutrition and health promotion

 

An avid reader and participant in a monthly book club

 

Travelling (recent trips include Mexico, South Korea, China, India and the United Kingdom)

 

Strong supporter and advocate of Amnesty International and the World Society of the Protection of Animals (WSPA).

 

 

JOURNAL PUBLICATIONS

 

Patel BP, Hamadeh MJ. Nutritional and exercise-based interventions in the treatment of Amyotrophic lateral sclerosis (ALS).  Clin Nutr 2009 (accepted on June 2, 2009; ms # YCLNU-D-08-00432R2) . Tables 1-7.

 

Seevaratnam R, Patel BP, Hamadeh MJ. Comparison of total protein concentration in skeletal muscle as measured by the Bradford and Lowry assays. J Biochem 2009;145:791–7. Abstract

 

 

ABSTRACTS


Patel BP, Tarnopolsky MA, Hamadeh MJ. Long-term caloric restriction increases apoptosis and decreases cell stress response, despite an elevation in antioxidant enzyme capacity in the skeletal muscle of the Cu/Zn-SOD mutant G93A mouse, an animal model of ALS. FASEB J 2009;23:109.1 (abst.). Abstract

 

Patel BP, Tarnopolsky MA, Hamadeh MJ. Caloric restriction increases skeletal muscle apoptosis in the G93A mouse due     to impairment in cell stress response and an incomplete compensatory upregulation of antioxidant enzymes. Proceedings of the Ontario Exercise Physiology Conference (2009) (abst.)

 

Patel B, Raha S, Tarnopolsky MA, Hamadeh MJ. Oxidative damage, antioxidant enzymes and mitochondrial energetics following caloric restriction in an animal model of heightened oxidative stress. Proceedings of the 1St Canadian Obesity Student Meeting 2008:23 (abst.).

 

Patel BP, Raha S, Tarnopolsky MA, Hamadeh MJ. Long-term caloric restriction up-regulates antioxidant protein content in female, but exacerbates disease outcomes in male, G93A mice, an animal model of amyotrophic lateral sclerosis (ALS). Proceedings of the CSCN-CSNS Annual Scientific Meeting 2008:SUP13 (abst.).

 

Seevaratnam R, Patel B, Hamadeh MJ. The Bradford assay proves superior to the Lowry assay in determining protein concentration for comparison of nutrient protein interactions in skeletal muscle. Proceedings of the CSCN-CSNS Annual Scientific Meeting 2008:SUP14 (abst.).

 

Patel BP, Raha S, Tarnopolsky MA, Hamadeh MJ. Long-term caloric restriction causes dysregulation in cellular redox status in the skeletal muscle of the Cu/Zn-SOD mutant G93A mouse, an animal model of ALS. FASEB J 2008;22:155.7 (abst.). Abstract

 

Seevaratnam R, Patel B, Hamadeh MJ. Determination of protein concentration in skeletal muscle using two spectrophotometric assays: the Lowry and the Bradford. FASEB J 2008;22:LB252 (abst.). Abstract

 

Patel BP, Raha S, Tarnopolsky MA, Hamadeh MJ. Long-term caloric restriction increases lipid peroxidation and up-regulates Cu/Zn-SOD and UCP3 protein content in the skeletal muscle of the female Cu/Zn-SOD mutant G93A mouse, an animal model of ALS. Proceedings of the Ontario Exercise Physiology Conference 2008:27 (abst.).

 

Seevaratnam R, Patel BP, Hamadeh MJ. To Lowry or to Bradford: validation of 2 spectrophotometric methods for the determination of protein concentration in skeletal muscle. Proceedings of the Ontario Exercise Physiology Conference 2008:26 (abst.).

 

Patel BP, Safdar A, Raha S, Tarnopolsky MA, Hamadeh MJ. Long-term caloric restriction increases lipid peroxidation, but decreases protein oxidation, in the skeletal muscle of the Cu/Zn-SOD mutant G93A mouse, an animal model of ALS. FASEB J 2007;21(6):A818 (abst.). Abstract

 

Patel BP, Hamadeh MJ, Raha S, Tarnopolsky MA. Long-term caloric restriction increases malondialdehyde in the red and white gastrocnemius muscle in the Cu/Zn-SOD mutant G93A mouse, an animal model of ALS. 19th Annu Ontario Biol Day Abstract Book 2006:27 (abst.). http://www.uwo.ca/biology/ontariobiologyday/AbstractBook.pdf Abstract

 

 

INVITED TALKS

 

February 2006                           ART: Residence Life Conference, Trent University,

“Unmasking Identity: Discovering the Colours of Your Life”

 

 

CONFERENCE PRESENTATIONS


Patel BP, Tarnopolsky MA, Hamadeh MJ. Long-term caloric restriction increases apoptosis and decreases cell stress response, despite an elevation in antioxidant enzyme capacity in the skeletal muscle of the Cu/Zn-SOD mutant G93A mouse, an animal model of ALS. Experimental Biology ‘09, New Orleans, LA, April 18-22, 2009 (podium presentation).

 

Patel BP, Tarnopolsky MA, Hamadeh MJ. Caloric restriction increases skeletal muscle apoptosis in the G93A mouse due     to impairment in cell stress response and an incomplete compensatory upregulation of antioxidant enzymes. Ontario Exercise Physiology Conference, Barrie, ON, January 23-25, 2009 (podium presentation).

 

Patel B, Raha S, Tarnopolsky MA, Hamadeh MJ. Oxidative damage, antioxidant enzymes and mitochondrial energetics following caloric restriction in an animal model of heightened oxidative stress. 1St Canadian Obesity Student Meeting, Laval, QUE, June 4-6, 2008 (podium presentation). http://obesity.ulaval.ca/upload/documents/PresentationSchedule.pdf

 

Patel BP, Raha S, Tarnopolsky MA, Hamadeh MJ.  Long-Term Caloric Restriction Up-Regulates Antioxidant Protein Content in Female, But Exacerbates Disease Outcomes in Male, G93A Mice. 7th Annual Scientific meeting of the Canadian Society of Clinical Nutrition – Canadian Society for Nutritional Sciences Toronto, ON, May 29 - 31, 2008 (poster presentation).

 

Patel B, Raha S, Tarnopolsky MA, Hamadeh MJ. Long-term caloric restriction causes dysregulation in cellular redox status in the skeletal muscle of the Cu/Zn-SOD mutant G93A mouse, an animal model of ALS. Experimental Biology ‘08, San Diego, CA, April 5-9, 2008 (podium presentation).

 

Patel B, Raha S, Tarnopolsky MA, Hamadeh MJ. Long-term caloric restriction increases lipid peroxidation and up-regulates Cu/Zn-SOD and UCP3 protein content in the skeletal muscle of the female Cu/Zn-SOD mutant G93A mouse, an animal model of ALS. Ontario Exercise Physiology Conference, Barrie, ON, January 25-27, 2008 (podium presentation).

 

Patel BP, Safdar A, Raha S, Tarnopolsky MA, Hamadeh MJ. Long-term caloric restriction increases lipid peroxidation, but decreases protein oxidation, in the skeletal muscle of the Cu/Zn-SOD mutant G93A mouse, an animal model of ALS. EB 2007, Washington DC, April 28-May 2, 2007 (poster presentation).

 

Patel BP, Hamadeh MJ, Raha S, Tarnopolsky MA. Long-term caloric restriction increases malondialdehyde in the red and white gastrocnemius muscle in the Cu/Zn-SOD mutant G93A mouse, an animal model of ALS. 19th Annu Ontario Biol Day, London, ON, March 18-19, 2006 (podium presentation).

 

 

MANUSCRIPTS IN PREPARATION

 

Patel BP, Safdar A, Raha S, Tarnopolsky MA, Hamadeh MJ. Long-term caloric restriction hastens clinical onset, disease progression and endpoint in the Cu/Zn-SOD mutant G93A mouse, an animal model of Amyotrophic lateral sclerosis (ALS).


 

 

 


 

 

Last updated: January 30, 2009