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X-ORIGINAL-URL:https://www.yorku.ca/science/chemistry/
X-WR-CALNAME:Department of Chemistry
X-WR-CALDESC:Department of Chemistry
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CLASS:PUBLIC
UID:MEC-1177967c7957072da3dc1db4ceb30e7a@yorku.ca
DTSTART:20230505T150000Z
DTEND:20230505T160000Z
DTSTAMP:20230424T133700Z
CREATED:20230424
LAST-MODIFIED:20240415
PRIORITY:5
SEQUENCE:2
TRANSP:OPAQUE
SUMMARY:Development of the first brain penetrant BRD4 inhibitors for cancer
DESCRIPTION:TITLE:  Development of the first brain penetrant BRD4 inhibitors for cancer\nABSTRACT.  Our research at X-Chem Montreal (formerly Intellisyn Pharma) focusses on the discovery and development of novel drugs for central nervous system (CNS) disorders, cancer, infection, and metabolic disorders. In this seminar, we will first describe the development of CNS-penetrant BRD4 inhibitors for cancer from initial concept to Phase-1.\n Bio:  \nJeffrey Albert.  Jeff did his PhD at the University of Pittsburgh and post-doc at Caltech.  He then joined AstraZeneca where he spent 15 years at their sites in the US and in Montreal.  Over 15 years his work focused on lead generation, fragment-based drug discovery and CNS therapeutics.  In 2012 he founded “IntelliSyn Pharma” in Montreal to continue research in CNS therapeutics, and in 2016 founded “Avisyn Pharma” in San Diego.  In the last 10 years, IntelliSyn has over 40 patent applications and developed 9 drugs that are now in Phase-1 and beyond.  In 2021 IntelliSyn was acquired by X-Chem in Boston, and Jeff continues in Montreal and serves as Executive VP and Director of Medicinal Chemistry.\n \nMeet with us!  If you would like to schedule an on-site interview or just an informal introductory meeting, click here.\n\nJeffrey Albert\nX Chem, Inc.\ne: jalbert@x-chemrx.com\n| w: www.x-chemrx.com\na: 7171 Frederick Banting , Montreal , QC Canada\nH4S 1Z9\n \n \n \n \n
URL:https://www.yorku.ca/science/chemistry/events/development-of-the-first-brain-penetrant-brd4-inhibitors-for-cancer/
LOCATION:PSE 317
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