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Weston Family Foundation - Proof-of-Principle Program

Opportunity NameProof-of-Principle: Microbial biomarkers of disease and therapeutic response
AgencyWeston Family Foundation
ValueUp to $300,000
Indirect CostsIneligible
Duration30 months

Letter of Intent (LOI)

LOI due to FSc RO at for full review05-21-2024
LOI and fully signed ORS checklist due to FSc RO at for mandatory review05-28-2024
LOI and fully signed ORS checklist due to ORS for mandatory review05-31-2024, by 10:00AM
LOI due at agency 06-04-2024, by 2:00PM


Proposal due to FSc RO at for full review08-08-2024
Proposal and fully signed ORS checklist due to FSc RO at for mandatory review08-15-2024
Proposal and fully signed ORS checklist due to ORS for mandatory review08-20-2024, by 10:00AM
Proposal due at agency 08-22-2024, by 2:00PM

Aims to support high-impact projects that seek to identify, validate, or apply microbiome-based biomarkers of disease and therapeutic response.

Eligible projects will:

  • Evaluate compositional or functional microbiome biomarkers.
  • Build on established responder/non-responder phenotypes towards the optimization of therapeutic or preventative strategies.

  • The Foundation is only able to accept Letters of Intent (‘LOIs’ and each an ‘LOI’) and Proposals (‘Proposals’ and each a ‘Proposal’) from institutions (or individuals affiliated with and applying through or on behalf of institutions) that are Canada Revenue Agency qualified donees in Canada.
  • Funds can also be used to support the Canadian portion of collaborations with members from other geographies.
  • The Principal Applicant must be a researcher working in Canada at least 50% of the time and at or above the level of Assistant Professor or equivalent, at a CRA-qualified donee in Canada.
  • Postdoctoral Fellows may apply as Principal Applicants, however, in such cases the project must include an Administrative Supervisor acting as a co-applicant, who has authorization to administer research accounts and is granted the relevant signing authorization.

How to Apply

York University researchers are reminded that all applications for external research funding, including Letters of Intent, must be reviewed and approved by the Office of Research Services before they are submitted to the granting agency.  For internal approval, the application must be accompanied by a completed ORS Checklist, which requires the Dean’s signature.  Please send the complete application, with the finalized budget and a completed ORS checklist to, five days prior to agency deadline.

ORS is accepting electronic applications – the process is outlined here.

For specific questions, please contact FSc Research Services at