{"id":16560,"date":"2011-03-03T00:00:00","date_gmt":"2011-03-03T04:00:00","guid":{"rendered":"https:\/\/yfiledev.uit.yorku.ca\/2011\/03\/03\/york-researchers-uncovering-how-ovarian-cancer-resists-chemotherapy\/"},"modified":"2025-04-01T15:09:57","modified_gmt":"2025-04-01T19:09:57","slug":"york-researchers-uncovering-how-ovarian-cancer-resists-chemotherapy","status":"publish","type":"post","link":"https:\/\/www.yorku.ca\/yfile\/2011\/03\/03\/york-researchers-uncovering-how-ovarian-cancer-resists-chemotherapy\/","title":{"rendered":"York researchers uncovering how ovarian cancer resists chemotherapy"},"content":{"rendered":"

<\/p>\n

York University researchers have zeroed in on a genetic process that may allow ovarian cancer to resist chemotherapy.<\/p>\n

Researchers in the University\u2019s Faculty of Science & Engineering studied a tiny strand of our genetic makeup known as a microRNA, involved in the regulation of gene expression. Cancer occurs when gene regulation goes haywire.<\/p>\n

\u201cOvarian cancer is a very deadly disease because it\u2019s hard to detect,\u201d says biology Professor Chun Peng, who co-authored the study. By the time it's diagnosed, usually it is in its late stages. And by that point there\u2019s really no way to treat the disease. Even when the disease is discovered in its early \"\"stages, chemotherapy doesn\u2019t always work,\u201d she says.<\/p>\n

Right: Chun Peng<\/strong><\/p><\/blockquote>\n

Peng was among a team of researchers that discovered a receptor, ALK7, that induces cell death in epithelial ovarian cancer cells. They have now discerned that microRNA 376c targets this crucial receptor, inhibiting its expression and allowing ovarian cancer cells to thrive.<\/p>\n

\u201cOur evidence suggests that microRNA 376c is crucial to determining how a patient will respond to a chemotherapeutic agent,\u201d says Peng. \u201cIt allows cancer cells to survive by targeting the very process that kills them off,\u201d she says.<\/p>\n

In examining tumours taken from patients who were non-responsive to chemotherapy, researchers found a higher expression of microRNA 376c and a much lower expression of ALK7.<\/p>\n

Peng believes that this research is a step towards being able to make chemotherapy drugs more effective in the treatment of the disease.<\/p>\n

\u201cFurther study is needed, but ultimately if we can introduce anti-microRNAs that would lower the level of those microRNAs that make cancer cells resistant to chemotherapeutic drugs, we will be able to make chemotherapy more effective against ovarian cancer,\u201d Peng says.<\/p>\n

She urges women to educate themselves about the risk factors and symptoms of the disease. For more information, visit Ovarian Cancer Canada<\/a>.<\/p>\n

Peng is a world expert in the area of ovarian cancer and the molecular basis of complications in pregnancy. Her research on chemo-resistance has also contributed to knowledge and prediction of pre-eclampsia, a pregnancy disorder that is a leading cause of maternal and perinatal complications and death.<\/p>\n

The article, \u201cMicroRNA 376c enhances ovarian cancer cell survival by targeting activin receptor-like kinase 7: implications for chemoresistance\u201d, was published in the Journal of Cell Science<\/em>.<\/p>\n

The study\u2019s lead author, Gang Ye, is a research associate in Peng\u2019s lab. Several trainees in Peng\u2019s lab, as well as scientists in Toronto\u2019s Sunnybrook Research Institute and in China also participated in the project.<\/p>\n

The research was supported by an operating grant from the Canadian Institutes of Health Research<\/a> (CIHR) and a mid-career award to Peng from the Ontario Women\u2019s Health Council\/CIHR. Ye was supported in part by a fellowship from the Toronto Ovarian Cancer Research Network.<\/p>\n","protected":false},"excerpt":{"rendered":"

The biology researchers have zeroed in on a genetic process that may allow ovarian cancer to resist chemotherapy...<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","footnotes":""},"categories":[11],"tags":[63,61,21],"yfileauthor":[],"qualifier":[],"yfile-author":[],"tags-to-show":[162,154],"workflow":[],"class_list":["post-16560","post","type-post","status-publish","format-standard","hentry","category-latest-news","tag-faculty-of-health","tag-science","tag-research","tags-to-show-faculty-of-health","tags-to-show-research"],"acf":{"internal_publish_date":null,"original_image":null},"yoast_head":"\nYork researchers uncovering how ovarian cancer resists chemotherapy - YFile<\/title>\n<meta name=\"robots\" content=\"index, follow, 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