{"id":218831,"date":"2015-05-07T16:39:09","date_gmt":"2015-05-07T20:39:09","guid":{"rendered":"https:\/\/yfiledev.uit.yorku.ca\/?p=218831"},"modified":"2025-04-02T10:16:27","modified_gmt":"2025-04-02T14:16:27","slug":"cancer-drugs-approved-quickly-but-not-to-patients-benefit-york-u-researcher","status":"publish","type":"post","link":"https:\/\/www.yorku.ca\/yfile\/2015\/05\/07\/cancer-drugs-approved-quickly-but-not-to-patients-benefit-york-u-researcher\/","title":{"rendered":"Cancer drugs approved quickly but not to patient's benefit: York U researcher"},"content":{"rendered":"
\"Joel

Dr. Joel Lexchin<\/p><\/div>\n

High priced cancer drugs get rushed approvals despite poor trial methodology and little effect on the longevity of patients, cautions Dr. Joel Lexchin, a physician and researcher at the School of Health Policy and Management in the Faculty of Health.<\/p>\n

\u201cPatients and their doctors should demand that regulators require pharma companies to provide clear evidence of clinical effectiveness of the drugs, resulting from rigorous methodology,\u201d suggests Lexchin. \u201cDrug agencies like the Food and Drug Administration (FDA) and the European Medicine Agency (EMA) don\u2019t actually look at whether people live longer.\u201d<\/p>\n

Lexchiin and co-author Donald Light, a professor in the School of Osteopathic Medicine, Rowan University in New Jersey, note in an article published in the British Medical Journal<\/em> titled \u201cWhy do cancer drugs get such an easy ride?\u201d that accelerated approval and shortened review times also make it a smooth sail for cancer drugs.<\/p>\n

Lexchin cites earlier research reviewing solid cancer drugs within 10 years of EMA approval to point out that these drugs improved survival by just over a month.<\/p>\n

\u201cSimilarly 71 drugs approved by the FDA from 2002 to 2014 for solid tumours have resulted in median gains in progression-free and overall survival of only 2.5 and 2.1 months, respectively,\u201d he says, \u201calso, only 42 per cent met the American Society of Clinical Oncology Cancer Research Committee\u2019s criteria for meaningful results for patients.\u201d<\/p>\n

The authors observe that pharmaceutical companies are having an easy ride with the European and US regulators, who are allowing them to test cancer drugs using surrogate measures instead of survival and other patient-centred measures.<\/p>\n","protected":false},"excerpt":{"rendered":"

High priced cancer drugs get rushed approvals despite poor trial methodology and little effect on the longevity of patients, cautions Dr. Joel Lexchin, a physician and researcher at the School of Health Policy and Management in the Faculty of Health at York 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