The laboratory is developing and using
novel methods for biomedical application including:
1. Assembly/disassembly of protein
machines on DNA
2. Highly-sensitive analyses of
regulatory RNA (e.g. microRNA)
3. Cancer diagnosis and treatment
4. Biomarker discovery
5. Selection of smart diagnostic probes and drug candidates from
combinatorial libraries
6. Analyses in capillary microreactors
7. Analysis of proteins and nucleic acids in single cells
The methods being developed are:
1. Kinetic Capillary Electrophoresis
(KCE)
2. Chemical Cytometry
3. Mixing in capillaries by Transverse Diffusion of Laminar Flow
Profiles (TDLFP)
4. Aptamer-facilitated Biomarker Discovery
5. Aptamer-facilitated Protein Isolation from Cells (AptaPIC)
6. Aptamer-facilitated detection of tumors
7. Hybridization analyses enhanced by DNA-binding proteins
8. Non-orthogonal free-flow electrophoresis
We conduct our biological research at
the cellular and small-animal level and
use
our
own
technologies
as
well as existing instrumental methods such
as:
1. Confocal microscopy
2. Flow Cytometry
3. Whole-body imaging
4. Real time Polymerase Chain Reaction (PCR)
Calculation of temperatures in
the efficiently- and inefficiently-colled sections of the capillary by
Universal Method for Determining Electrolyte Temperatures in Capillary
Electrophoresis Excel
file
for
Excel
2007
