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Future Students ï Current Students ï Faculty & Staff ï Visitors ï YorkU Organization ï York Tour |
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Scope of Research |
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Our research combines
basic study aimed at understanding and controlling the self-assembly of
lipids, polymer-grafted molecules and biomolecules at surfaces and interfaces
with applied study concerned with the engineering of membrane-mimetic
surfaces for use as tissue-contacting coatings on the surface of implantable
materials and vesicles for drug delivery. Currently, our research is focused
on polymer-grafted membrane-mimetic surfaces and their interactions with dissolved
biomolecules, e.g. serum proteins and enzymes. Major objectives of our
research are (1) to study the effect of polymer-grafted lipids on the lateral
structure of polymer-grafted membrane-mimetic surfaces; (2) to examine the
effect of polymer-grafted lipids on local surface properties such as local
composition, physical state, hydration and electrostatic properties of
polymer-grafted membrane-mimetic surfaces; and (3) to elucidate the role of
lateral structure and local surface properties in interactions of polymer-grafted
membrane-mimetic surfaces with dissolved biomolecules. The knowledge obtained
in these studies will then be used as general guidelines to the preparation
of bio-non-fouling coatings on the surface of implanted medical devices and stealth
liposomes for drug delivery. Our research is performed
mainly with lipid monolayers that are either spread at the air/water
interface or deposited on solid substrates using Langmuir-Blodgett method. Experimental
techniques we use to conduct our research include epifluorescence microscopy,
fluorescence spectroscopy, atomic force microscopy, ellipsometry and Brewster
angle microscopy. |
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Selected Publications |
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– |
Tsukanova,
V.; Salesse, C. On the Nature
of Conformational Transition in Poly(ethylene glycol) Chains Grafted onto
Phospholipid Monolayers. J. Phys. Chem. B. 2004, 108(30),
10754-10764. PDF (144k) |
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– |
Tsukanova,
V.; Salesse, C. High-Pressure
Transition of a Poly(ethylene glycol)-Grafted Phospholipid Monolayer at the
Air/Water Interface. Macromolecules
2003,
36(19),
7227-7235. PDF (674k) |
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– |
Tsukanova,
V.; Grainger, D. W.; Salesse, C. Monolayer
Behavior of NBD-Labeled Phospholipids at the Air/Water Interface. Langmuir 2002, 18(14),
5539-5550. PDF (268k) |
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– |
Tsukanova,
V.; Lavoie, H.; Harata, A.; Ogawa, T.; Salesse, C. Microscopic
Organization of Long-Chain Rhodamine Molecules in Monolayers at the Air/Water
Interface. J. Phys. Chem. B.
2002, 106(16),
4203-4213. PDF (222k) |
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Research Funding |
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2004 |
NSERC UFA Discovery Grant “Polymer-Grafted
Membrane-Mimetic Surfaces: Lateral Structure and Interactions with Dissolved Biomolecules” |
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2004 |
NSERC Research Tools and Instruments
Grant “Epi-Fluorescence
Microscope for in-situ Characterization of
Polymer-Grafted Membrane-Mimetic Surfaces” |
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2005 |
NSERC Research Tools and Instruments
Grant “Langmuir Trough for In-Situ
Epi-Fluorescence Microscopy Study of Monolayers Spread on Aqueous Subphases” |
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2005 |
York Junior Faculty Fund Equipment Grant
“Imaging Chamber for In-Situ Visualization
of Binding of Dissolved Biomolecules onto Polymer-Grafted Membrane-Mimetic
Surfaces” |
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Last updated: June 15th, 2005 |
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