Sergey N. Krylov has obtained a Ph.D. degree in Biophysical Chemistry at Lomonosov Moscow State University in 1990, where he studied enzymatic reactions which produce chemiluminescence. He continued this work in Dr. Dunford's laboratory at the University of Alberta, where he was able to elucidate the mechanism of non-linear behaviors in inhibition of chemiluminescent enzymatic reactions by phenols. In 1996 Dr. Krylov joined the laboratory of Dr. Dovichi at the University of Alberta, where they pioneered instrumentation and methods for Chemical Cytometry, a powerful technique which allows the analysis of chemical contents of individual cells.
Dr. Krylov's first faculty appointment was made at the Associate Professor level at York University in 2000. He was advanced to full professorship within 6 years. In 2020, Dr. Krylov became Distinguished Research Professor. Research in Dr. Krylov's laboratory has been focused on development of novel bioanalytical tools. Some examples of successful technologies developed in the lab include:
- Kinetic Capillary Electrophoresis (KCE) - a highly-versatile analytical tool that facilitates drug lead selection from combinatorial libraries and kinetic characterization of selected drug candidates.
- Non-SELEX - an approach to selection of DNA aptamers which is 10-times faster than conventional methods.
- Transverse Diffusion of Laminar Flow Profiles (TDLFP) - a technique for efficient mixing in capillary microreactors, a fast-developing field on the boundary of synthetic, physical, and analytical chemistry.
- Accurate Constant by Transient Incomplete Separation (ACTIS) - a method for finding accurate Kd value of protein–small molecule complexes.
According to Google Scholar, Dr. Krylov's publications have been cited over 7000 times, and have a cumulative h-index value of 47. His bioanalytical methods are being used by dozens of biology and chemistry laboratories and multiple companies around the world. In recognition of his achievements, Dr. Krylov was appointed as Canada Research Chair (tier II) in 2003, and re-appointed in 2008. In November 2009 Dr. Krylov was elected as the inaugural director of Centre for Research on Biomolecular Interactions. He held York University Research Chair in Bioanalytical Chemistry from 2015 to 2020.
|1987 - 1990||Doctor of Philosophy, Biophysical Chemistry, Lomonosov Moscow State University|
|1981 - 1987||Master of Science, Physics, Lomonosov Moscow State University|
|Nov 2009 - Jul 2014
Jun 2015 - Present
|Director, Centre for Research on Biomolecular Interactions, York University|
|Jul 2006 - Present||Professor, York University|
|Jul 2000 - Jun 2006||Associate Professor, York University|
|Aug 1994 - Jun 2000||Research Associate, University of Alberta|
|Jan - Jul 1994||Visiting Scientist, University of Waterloo|
|May 1990 - Jan 1994||Research Scientist, Lomonosov Moscow State University|
|Oct - Dec 2015||Visiting Fellowship, The São Paulo Research Foundation|
|Feb - Mar 2015||Visiting Fellowship, University of Tasmania|
|Jul 2015 - Jun 2020||York University Chair in Bioanalytical Chemistry, York University|
|Feb 2015||President's Research Excellence Award, York University|
|May 2014||Maxxam Award, Canadian Society for Chemistry|
|Oct 2003 - Sep 2013||Canada Research Chair in Bioanalytical Chemistry, Natural Sciences and Engineering Research Council of Canada|
|Jul 2007||W.A.E. McBryde Medal, Canadian Society for Chemistry|
|Jun 2002||Young Investigators Award, Petro-Canada|
|Jun 2000||Research Innovation Award, Research Corporation for Science Advancement|
|Oct 2000||Premier’s Research Excellence Award, Ontario Ministry of Energy, Science and Technology|