Miyake, T., Aziz, A., & McDermott, J. C. (2020). Maintenance of the Undifferentiated State in Myogenic Progenitor Cells by TGFβ Signaling is Smad Independent and Requires MEK Activation. International journal of molecular sciences, 21(3), 1057. https://doi.org/10.3390/ijms21031057 Significance of the research: Transforming growth factor β (TGFβ) is a pluripotent cytokine that has potent effects on skeletal […]
Mann, G., & Adegoke, O. (2021). Effects of ketoisocaproic acid and inflammation on glucose transport in muscle cells. Physiological reports, 9(1), e14673. https://doi.org/10.14814/phy2.14673 Significance of the research: Type 2 diabetes and cardiovascular diseases affect millions of people world-wide, with the attending implications for morbidity and mortality. An underlying cause of these diseases is insulin resistance, especially skeletal […]
Da Eira, D., Jani, S., Sung, H., Sweeney, G., & Ceddia, R. B. (2020). Effects of the adiponectin mimetic compound ALY688 on glucose and fat metabolism in visceral and subcutaneous rat adipocytes. Adipocyte, 9(1), 550–562. https://doi.org/10.1080/21623945.2020.1817230 Significance of the research: Adiponectin is an adipose-derived hormone that is significantly reduced in the blood of obese and type 2 diabetic […]
Nardone M, Guzman J, Harvey PJ, Floras JS, Edgell H. Effect of a neck compression collar on cardiorespiratory and cerebrovascular function in postural orthostatic tachycardia syndrome (POTS). J Appl Physiol (1985). 2020;128(4):907‐913. doi:10.1152/japplphysiol.00040.2020 Significance of the research: Postural orthostatic tachycardia syndrome (POTS) is marked by an excessive increase of heart rate in the upright posture […]
Zhao Y, Rafatian N, Backx PH, et al. Engineering microenvironment for human cardiac tissue assembly in heart-on-a-chip platform. Matrix Biol. 2020;85-86:189-204. doi:10.1016/j.matbio.2019.04.001 Significance of the research The generation of heart tissues from pluripotent stem cells is hampered by the lack of cellular maturation as well as problems with cellular composition. In addition to cardiomyocytes, […]
Insulin, the most important hormone for the control of metabolism in the body, was discovered 100 years ago by Fredrick Banting, Charles Best and James Collip under the directorship of Professor John Macleod at the University of Toronto. The discovery of insulin earned Banting and Macleod the Nobel Prize in 1923, and people around the […]