Biology Graduate Program, Physics and Astronomy Graduate Program Eligible to Supervise
ContactOffice Location 331C LSB
Phone Number (416)736-2100 x 20786 (Voicemail)
Protein Dynamics, Microfluidics, Time-resolved Mass Spectrometry, Biophysical NMR
Research is focused on the relationship between the conformational motions of proteins in solution (their dynamics) and their biological activity. The primary tool is Time- Resolved Electrospray Mass Spectrometry, a method that allows a wide range of active biochemical processes to be monitored on short (millisecond-to-second) timescales. This technique is combined with a number of other techniques, including biophysical NMR and H/D exchange to obtain a highly detailed, dynamic picture of protein function. There is also a significant technology development component to the work.