Biological Chemistry, Nucleic Acid Chemistry, Biophysical Chemistry, Biomolecular NMR
Three-dimensional structure determination of RNA molecules and protein-RNA complexes. A combined approach of nuclear magnetic resonance (NMR) methods, molecular biology techniques, and other biophysical methods to study and determine the structure of RNA molecules and protein-RNA complexes. Modern multi-dimensional multi-nuclear NMR methods that utilize isotopically enriched (13C, 15N, 2H) protein or RNA molecules are used for NMR analysis, while molecular biology techniques are used to produce the protein and RNA samples for structural studies.
Affiliated with the Centre for Research on Biomolecular Interactions (CRBI)