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OICR Cancer Therapeutics Innovation Pipeline Program

Opportunity NameCancer Therapeutics Innovation Pipeline (CTIP) Program
AgencyOntario Institute for Cancer Research (OICR)
ValueEarly Validation projects – Up to $150,000/year
Early Accelerator projects – Up to $150,000
Indirect CostsEligible at 30%
DurationEarly Validation projects – Up to 2 years
Early Accelerator projects – Up to 1 year

Letter of Intent (LOI)

Note: The deadline for submission of the Notice of Intent (NOI) is the same as the deadline for Letter of Intent (LOI) submission, however, applicants are encouraged to submit their NOI as early as possible to assist with planning and to ensure sufficient time to complete the LOI by the deadline.

Notice of Intent (NOI) due at agency05-16-2024, by 5:00PM
LOI due to FSc RO at for full review05-02-2024
LOI and fully signed ORS checklist due to FSc RO at for mandatory review05-09-2024
LOI and fully signed ORS checklist due at ORS for mandatory review05-14-2024, by 9:00AM
LOI due at agency 05-16-2024, by 5:00PM

Full application (by invitation only)

Application due to FSc RO at for full review08-15-2024
Application and fully signed ORS checklist due to FSc RO at for mandatory review08-22-2024
Final application and fully signed ORS checklist due at ORS for mandatory review08-27-2024, by 9:00AM
Application due at agency 08-29-2024, by 5:00PM
  • To create a pipeline of validated cancer targets and first-in-class or best-in-class, novel, selective lead molecules (small molecules or biologics) that will attract partnerships and/or investment for further preclinical and clinical development; and
  • Support projects that aim to provide increasing evidence of target validation and disease association using data from knowledge bases, functional assays, and drug screening in relevant in vitro and in vivo models of the cancer type of interest.

CTIP funds projects in four stages of preclinical drug discovery and is currently inviting applications for the following funding streams:

Early Validation projects: Deliver robust translational evidence that a Target-of-Interest (TOI) is associated with a specific cancer type based on data from knowledge bases and from studies demonstrating that perturbation of the TOI in relevant cell-based or higher models produces anti-cancer effects sufficient to trigger a drug discovery campaign.

Early Accelerator projects: Deliver a validated primary assay to enable initial screening of molecules against a defined target. Preliminary evidence of linearity of results between the primary assay and supporting secondary assays under development is also required.


OICR invites applications from investigators at Ontario academic centres, hospital research institutes, or other government research institutions. CTIP funding is only tenable in Ontario. For-profit entities are not eligible to apply. 


An information session will be held on April 24, 2024 from 2:00–3:00 PM EST.

How to Apply

York University researchers are reminded that all applications for external research funding, including Letters of Intent, must be reviewed and approved by the Office of Research Services before they are submitted to the granting agency.  For internal approval, the application must be accompanied by a completed ORS Checklist, which requires the Dean’s signature.  Please send the complete application, with the finalized budget and a completed ORS checklist to, five days prior to agency deadline.

ORS is accepting electronic applications – the process is outlined here.

For specific questions, please contact FSc Research Services at